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Norex 50 mg ifa

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Description

Norex 50 mg ifa

Norex 50 mg ifa is indicated as an adjunct in the treatment of exogenous obesity, associated with a hypocaloric diet and exercise.

CLINICAL PHARMACOLOGY

Amfepramone is rapidly absorbed from the gastrointestinal tract after oral administration and is extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction, many of their metabolites are biologically active and may participate in the therapeutic action of IFA Norex.

Studies have reported that amfepramone and its metabolites can cross the blood brain barrier and placenta.

Amfepramone and its metabolites are excreted primarily by renal excretion, has been reported that 75% of the dose was recovered in the urine within 24 hours after dosing, plasma half-life of its metabolites is estimated between 4 and 6 hours.

CONTRAINDICATIONS

IFA Norex not be administered concurrently or 14 days after administration of monoamine oxidase, since it can result in hypertensive crisis should not be given to patients hypersensitive to amfepramone or idiosyncrasy to sympathomimetic amines, states of agitation or emotionally unstable individuals who are susceptible or history of drug or alcohol abuse.

It is contraindicated in patients with glaucoma, hyperthyroidism, advanced arteriosclerosis or severe hypertension, severe kidney disease, children under 12 years, pregnancy and lactation.

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